concept

CRH (Corticotropin-releasing hormone, CRF, corticotropin-releasing factor)

Corticotropin releasing factor (CRF) is a hypothalamic hormone, which acts on the anterior pituitary to stimulate the secretion of corticotropin, thereby regulating the synthetic/secretory activity of the adrenal cortex Vale et al (1981). CRF is widely distributed in the central nervous system and in the periphery. In addition to regulating the stress response, the CRF peptides have a wide variety of actions in the central nervous system and in the periphery, possibly regulating anxiety, mood, feeding, inflammation, gastric emptying, and blood pressure Dautzenberg and Hauger (2002). CRF is bound to a 37 kDa plasma binding protein, which inactivates CRF in the circulation Behan et al (1995).

Ref:
Brian L. Furman, Corticotropin Releasing Factor, Editor(s): S.J. Enna, David B. Bylund, xPharm: The Comprehensive Pharmacology Reference, Elsevier, 2007, Pages 1-4, ISBN 9780080552323, https://doi.org/10.1016/B978-008055232-3.61510-7.

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Added on Feb 9, 2022 by Barbara Van De Keer
Edited on Jan 10, 2023 by Barbara Van De Keer

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