concept

Ghrelin

Ghrelin is a 28–amino acid peptide predominantly produced by endocrine cells of the oxyntic glands in the stomach. Ghrelin appears to be under both endocrine and metabolic control, has a diurnal rhythm, and likely plays a major role in the neuroendocrine and metabolic responses to changes in nutritional status. Ghrelin has been shown to stimulate growth hormone release as well. Ghrelin levels are high during fasting and increases shortly before meals, with decreased levels after meals. Decreased ghrelin levels have been associated with gastritis. Within the stomach, ghrelin increases gastric emptying and motility and increases gastric acid secretion. In human volunteers, ghrelin administration enhances appetite and increases food intake.

Ref:
BOOK CHAPTER Stomach David A. Mahvi and David M. Mahvi Sabiston Textbook of Surgery, Chapter 49, 1196-1239

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Added on Apr 7, 2022 by Barbara Van De Keer
Edited on Oct 2, 2022 by Barbara Van De Keer

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