process

Fructose 6-phosphate synthesis

In adipose tissue and muscle, hexokinase phosphorylates fructose to synthesize fructose 6-phosphate, which then enters into glycolysis. Hexokinase, on the other hand, phosphorylates the majority of hexoses, including glucose. Furthermore, the Km of hexokinase for fructose is exponentially higher than that of glucose. Therefore, as glucose is a more favorable substrate for hexokinase, it competitively inhibits fructose phosphorylation by hexokinase.

Ref:
Dholariya SJ, Orrick JA. Biochemistry, Fructose Metabolism. [Updated 2021 Oct 25]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK576428/

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Added on Oct 2, 2022 by Barbara Van De Keer

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