process

Angiotensin 1 synthesis

Angiotensinogen is produced primarily in the liver and is secreted into the systemic circulation where it is converted into angiotensin I by the enzyme renin, which is secreted from the juxtaglomerular apparatus of the kidney. While other tissues express the gene responsible for producing the active renin enzyme, it is only the kidney that secretes the active renin, which is fully capable of enzymatic cleavage of angiotensinogen.

Ref:
James S.M. Cuffe, Sarah L. Walton, Karen M. Moritz, Chapter 15 - The Developmental Origins of Renal Dysfunction, Editor(s): Cheryl S. Rosenfeld, The Epigenome and Developmental Origins of Health and Disease, Academic Press, 2016, Pages 291-314, ISBN 9780128013830, https://doi.org/10.1016/B978-0-12-801383-0.00015-3. (https://www.sciencedirect.com/science/article/pii/B9780128013830000153)

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Added on Sep 26, 2022 by Barbara Van De Keer
Edited on Sep 28, 2022 by Barbara Van De Keer

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